JUVEDERM® is a gel filler used to instantly smooth out facial wrinkles. One treatment of JUVEDERM® can last up to a year! The most common problem areas where JUVEDERM® is used include the mouth and nose. With JUVEDERM®, smile lines and vertical lip lines disappear into young, healthy-looking skin! As people age, they tend to lose a hydrating substance called hyaluronic acid in their skin. JUVEDERM® is a safe and effective way to restore the HA your skin has lost.